Symposium ‘Metabolism Meets Virulence’

The second international symposium ‘Metabolism Meets Virulence’ is part of the DFG-funded priority program SPP1316: ‘Host-adapted metabolism of bacterial pathogens’. The SPP1316, 17 research groups currently investigate the mechanisms of bacterial metabolism during infection. The symposium will cover infection models for study of specific pathogens, regulation of metabolism during infection, analytical approaches for quantification of metabolomes and metabolic fluxes, as well as bioinformatics for quantification and modeling metabolism during invasion.

About 150 national and international speakers and participants are expected to join the symposium. These will include biologist and physicians working on infectious disease, analytical biochemists and bioinformaticians. The symposium is expected to demonstrate the recent progress in SPP1316 and to further foster interdisciplinary scientific collaboration.

The symposium Metabolism Meets Virulence 2 will be made possible by generous support by the DFG, Leopoldina and DGHM.

Program list is available: PDF

Metabolism Meets Virulence

2nd International Symposium on Metabolism and Bacterial Pathogenesis

SPP1316

We invite you to the second international symposium on

host-adapted bacterial metabolism during infection

The symposium is part of DFG priority programme SPP1316

TOPICS (tentative)

- Metabolomic profiling of pathogenic bacteria

- Modelling bacterial metabolism

- Global regulation of bacterial metabolism

- Adaptation to extracellular lifestyles

- Metabolism of intracellular bacteria

- Perspectives in bacterial pathogenesis and metabolism

Scientific committee:

Michael Hensel (Osnabrück)

Download MMV

Funding and support:

DFG, DGHM, LEOPOLDINA, BIOLOG, DIAGONAL and BRAND

 


Sunday, 6th of April 2014

Final program of Metabolism Meets Virulence 2:

April, 6th 2014, University Osnabrück, Castle

From 15:00 Registration
16:00-17:30 Workshop Biolog, Barry Bochner
18:00 Welcome by the speaker of SPP1316
18:15 Keynote Lecture, Chair: Michael Hensel
         Speaker: Andreas J. Bäumler, University of California Davis, USA
               How the host response feeds Salmonella

19:30 Reception, dinner and informal get together

Monday, 7th of April 2014

April, 7th 2014, Steigenberger Hotel Remarque

Session 1: Adaptation to extracellular lifestyles 1, Chair: Sven Hammerschmidt
08:30 Richard Proctor, Madison, USA: Staphylococcus aureus SCV persisters: Multiple metabolic mechanisms     
09:00 Christine Josenhans, Hannover, Germany: Energy sensing in pathogenic epsilonproteobacteria: hub between  metabolism and virulence functions
09:30 Andre Kriegeskorte, Münster, Germany: Common metabolic features of Staphylococcus aureus small colony-variants                                                                                                                                                                                     09:50 Jörg Willenborg, Hannover, Germany: Role of CcpA in the regulation of the metabolism and virulence of Streptococcus suis                                                             
10:10 Hasan Yesilkaya, UK: Studies on Pneumococcal Esterases
10:30 Coffee break
Session 2: Global regulation of bacterial metabolism, Chair: Petra Dersch
11:00 Jay C. D. Hinton, Liverpool, UK: Lag is the forgotten growth phase: What happens during the earliest stage of growth of a bacterial cell?
11:30 Jörg Stülke, Göttingen, Germany: c-di-AMP an emerging essential secondary messenger that links nutrient availability to cell wall synthesis
12:00 Christoph Schön, Würzburg, Germany: Stringent response in ex vivo survival of Neisseria menigitidis
12:20 Markus Bischoff, Homburg, Germany: Influence of catabolite control proteins on infectivity of Staphylococcus aureus
12:40 Tanja Kern, Freising, Germany: Host-adapted N-Metabolism of Listeria monocytogenes
13:00 Lunch

Session 3: Metabolism of intracellular bacteria, Chair: Werner Göbel
14:00 John McKinney, Lausanne, Switzerland: Non-Growing but Metabolically Active (NGMA) Phenotypic Variants
14:30 Michael Hensel, Osnabrück, Germany: A new view on the intracellular habitat of Salmonella enterica
14:50 Amanda Chidlaw, Norwich, UK: Adaptation of the intracellular metabolism of Salmonella Typhimurium to the host cell environment
15:10 Johannes Rothhardt, Freising, Germany: Link between myo-inositol metabolism and virulence in Salmonella Typhimurium
15:30 Coffee Break

Session 3 continued
16:00 Hubert Hilbi, Zurich, Switzerland: Metabolism of glycerol, inositol and phytate by Legionella and implications for virulence
16:20 Klaus Heuner, Berlin, Germany: The Metabolism of Legionella pneumophila Investigated by Isotopologue Profiling
16:40 Catherine Vilcheze, New York, USA: Phosphorylation of a beta-keto-acyl ACP synthase regulates cell wall composition, acid-fast staining and virulence in Mycobacterium tuberculosis
17:00 Poster session
19:30 Dinner at Rampendahl

Tuesday, 8th of April 2014

April, 8th 2014, Steigenberger Hotel Remarque; In the afternoon at Kalkriese "Varus Battle"

Session 4: Host microbiota and bacterial pathogens, Chair: Jürgen Heesemann
8:30 Tyrrell Conway, Oklahoma, USA: The Restaurant Hypothesis of Intestinal Colonization
9:00 Dirk Bumann, Basel, Switzerland: Salmonella metabolism heterogeneity in infected host tissues
9:30 Sebastian Winter, Dallas, TX, USA: Host-derived nitrate boosts growth of E. coli in the inflamed gut
9:50 Dirk Hofreuter , Hannover, Germany: Exploring the metabolic interface between the gastrointestinal pathogen Campylobacter, its host and the microbiota
10:10 Ivan Berg, Freiburg, Germany: Bacterial itaconate degradation promotes pathogenicity
10:30 Coffee break
Session 5: Adaptation to extracellular lifestyles 2, Chair: Gottfried Wilharm
11:00 Andreas Peschel, Tübingen, Germany: Nutrient limitation governs Staphylococcus aureus niche adaptation in the human nose
11:30 Emanuel Hanski, Jerusalem, Israel: An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation - group A Streptococcus as a paradigm
12:00 Sven Hammerschmidt, Greifswald, Germany: Regulation of the arginine deiminase system by ArgR2 couples pneumococcal metabolism and virulence
12:20 Petra Dersch, Braunschweig, Germany: Host-adapted metabolic functions important for Yersinia pseudotuberculosis virulence
12:40 Christine Heider, Wernigerode, Germany: Stable isotope labelling reveals a distinctive role of glutamine during operation of the Yersinia enterocolitica type three secretion system
13:00 Lunch

Varus battleground, Kalkriese
Excursion: Visit of the ‘Varus battleground Teutoburger Wald’
14:00 Busses to Varus battleground, Kalkriese
14:30 Arrival at Kalkriese
Coffee and refreshment provided
Session 6: Regulation of metabolism during host colonization, Chair: Michael Hensel
14:45 Kai Papenfort, Princeton, USA: Conserved and specific functions of the small regulatory RNA SgrS in Salmonella
15:15 Andrew Roe, Glasgow, UK: Sending pathogenic E. coli on an acid trip
15:45 David Clarke, Cork, Ireland: Specific metabolic pathways in adherent-invasive Escherichia coli are required for replication in the macrophage and activation of Il-1b production
16:05 Barbara Campanini, Parma, Italy: Blocking cysteine biosynthesis in Salmonella typhimurium: the moonlighting enzyme CysK as a potential antibiotic target
Coffee and refreshments provided
16:30 and 17:00 Excursion: Quintili Vare, legiones redde! Guided tours to the ‘Varus battleground Teutoburger Wald’ Exhibition site

19:00 Dress like a Roman - Demonstration of Roman clothing
20:00 Dine like a Roman - Conference Dinner

Wednesday, 9th of April 2014

April, 9th 2014, Steigenberger Hotel Remarque

Session 7: Future challenges in host-adapted bacterial metabolism, Chair: Thomas Dandekar
8:30 Nassos Typas, Heidelberg, Germany: From high-throughput approaches to molecular mechanism
9:00 Matthias Horn, Vienna, Austria: The metabolism of host-free chlamydiae
9:30 Alexander Westermann, Würzburg, Germany: Simultaneous gene expression analysis of pathogen and host by Dual RNA-seq
9:50 Wolfgang Eisenreich, Garching, Germany: Exploring pathways and interactions in the pathometabolism of bacteria
10:10 Namrata Iyer, Bangalore, India: Amino acid racemases: Novel regulators of Salmonella pathogenesis
10:30 Coffee break
Session 8: Modeling bacterial metabolism during infection, Chair: Wolfgang Eisenreich
11:00 Michael Lalk, Greifswald, Germany: Metabolomics insights in infection-related adaptations of Staphylococcus aureus
11:30 Kyu Y. Rhee, New York, USA: Mycobacterial metabolomics: towards a chemical understanding of essentiality
12:00 Thomas Dandekar, Würzburg, Germany: Modelling Metabolism in intracellular infections
12:20 Conclusion and closing remarks, Michael Hensel                        


12:30 Lunch (Lunch boxes on request)

Departure

Confirmed speakers include:

  • Andreas J. Baeumler (Davis, CA USA): How the host response feeds Salmonella
  • Dirk Bumann (Basel, Switzerland): Salmonella metabolism heterogeneity in infected host tissues
  • Tyrrell Conway (Oklahoma, USA): The restaurant hypothesis of intestinal colonization
  • Emanuel Hanski (Jerusalem, Israel): An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation-group A streptococcus as a paradigm
  • Matthias Horn (Vienna, Austria): The metabolism of host-free chlamydiae
  • Christine Josenhans (Hannover, Germany): Energy sensing in pathogenic epsilonproteobacteria: hub between metabolism and virulence functions
  • Jay C. D. Hinton (Liverpool, UK): Lag is the forgotten growth phase: What happens during the earliest stage of growth of a bacterial cell?
  • Michael Lalk (Greifswald, Germany), Metabolomics insights in infection-related adaptations of Staphylococcus aureus
  • John D. McKinney (Lausanne, Switzerland): Non-Growing but Metabolically Active (NGMA) Phenotypic Variants
  • Kai Papenfort (Princeton, USA): Conserved and specific functions of the small regulatory RNA SgrS in Salmonella
  • Andreas Peschel, (Tuebingen, Germany): Nutrient limitation governs Staphylococcus aureus niche adaptation in the human nose
  • Richard Procter (Madison, WI, USA): Staphylococcus aureus SCV Persisters: Multiple Metabolic Mechanisms
  • Kyu-Young Rhee (New York City, USA): Mycobacterial metabolomics: towards a chemical understanding of essentiality
  • Andrew Roe (Glasgow, UK): Sending pathogenic E. coli on an acid trip
  • Joerg Stuelke (Goettingen, Germany): c-di-AMP an emerging essential secondary messenger that links nutrient availability to cell wall synthesis
  • Nassos Typas (Heidelberg, Germany): From high-throughput approaches to molecular mechanism